An activatable endoplasmic reticulum-targeted probe for NIR imaging-guided photothermal therapy.

Chen, Rui; Wang, Rongchen; Sun, Jie; Dong, Xuemei; Dong, Chengjun; Sun, Lixin; Gu, Xianfeng; Zhao, Chunchang

Chen, Rui; Wang, Rongchen; Sun, Jie; Dong, Xuemei; Dong, Chengjun; Sun, Lixin; Gu, Xianfeng; Zhao, Chunchang.

Afiliación

Chen R; Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200
Wang R; Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200
Sun J; Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200
Dong X; Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200
Dong C; Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200
Sun L; Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200
Gu X; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China. xfgu@fudan.edu.cn.
Zhao C; Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200

Org Biomol Chem ; 21(29): 5919-5923, 2023 07 26.

Article en En | MEDLINE | ID: mdl-37435862

RESUMEN

An H2O2-activated, endoplasmic reticulum-targeted theranostic probe was developed. This designed probe could be activated by H2O2, resulting in increased NIR fluorescence and photothermal signals, thus achieving specific recognition of H2O2 and further photothermal therapy in the endoplasmic reticulum of H2O2-overexpressing cancer cells.

Asunto(s)

Nanopartículas; Neoplasias; Humanos; Terapia Fototérmica; Fototerapia/métodos; Peróxido de Hidrógeno; Nanomedicina Teranóstica/métodos; Retículo Endoplásmico; Línea Celular Tumoral

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Nanopartículas / Neoplasias Idioma: En Revista: Org Biomol Chem Año: 2023 Tipo del documento: Article