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Ethanol-Extracted Acorn Induces Anti-Inflammatory Effects in Human Keratinocyte and Production of Hyaluronic Acid in Human Fibroblasts.
Lee, Jungwhoi; Jo, Sung-Eun; Han, Song-I; Kim, Jae-Hoon.
Afiliación
  • Lee J; Department of Biotechnology, College of Applied Life Science, SARI, Jeju National University, Jeju, Korea.
  • Jo SE; ChanChanHee, Inc., Jeju, Korea.
  • Han SI; Department of Biotechnology, College of Applied Life Science, SARI, Jeju National University, Jeju, Korea.
  • Kim JH; Department of Biotechnology, College of Applied Life Science, SARI, Jeju National University, Jeju, Korea.
J Med Food ; 26(8): 595-604, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37594560
Acorn (Quercus acutissima CARR.) has been used in traditional food and medicinal ethnopharmacology in Asia, and it has shown multifarious functions such as antidementia, antiobesity, and antiasthma functions. However, there is limited scientific evidence about the efficacy of acorn for ameliorating skin problems. Treatment with ethanol-extracted acorns (EeA's) ablated the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX2), monocyte chemoattractant protein-1 (MCP-1), and interleukin (IL)-8 stimulated by tumor necrosis factor (TNF)-α in human adult low calcium high temperature (HaCaT) cells under sublethal dosages. In addition, treatment with EeA dose dependently inhibited the ex vivo hyper keratin formation induced by TNF-α in HaCaT cells in conjunction with the blockade of cytokeratin-1 (CK-1) and cytokeratin-5 (CK-5) expression. Moreover, EeA treatment stimulated the expression of hyaluronic acid (HA) expression in human fibroblasts in a dose-dependent manner. Linoleamide was identified as the functional component of EeA using preparative high-performance liquid chromatography and ultra high performance liquid chromatography-mass spectrometry-mass spectrometry analysis, and the anti-inflammatory features and enhanced HA expression were verified. Collectively, these results suggest the efficacy of EeA supplementation in improving skin problems via anti-inflammation and upregulating HA production.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Quercus / Ácido Hialurónico Tipo de estudio: Prognostic_studies Idioma: En Revista: J Med Food Año: 2023 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Quercus / Ácido Hialurónico Tipo de estudio: Prognostic_studies Idioma: En Revista: J Med Food Año: 2023 Tipo del documento: Article