The effect of oral treatment of royal jelly on the expression of the PDGF-ß gene in the skin wound of male mice.
J Tissue Viability
; 32(4): 536-540, 2023 Nov.
Article
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| MEDLINE
| ID: mdl-37679248
ABSTRACT
AIMS OF THE STUDY Royal jelly (RJ) is one of the most widely used drugs in traditional medicine. One of its important applications is the repair of skin damage, although the path of its mechanism is still unknown. Platelet-derived growth factor-beta (PDGF-beta) is one of the important factors in wound healing and it has been observed that PDGF-ß expression decreases with increasing age. In this study, for the first time, the effect of RJ on skin wounds has been investigated through the expression of PDGF-ß and tissue studies. MATERIALS AND METHODS:
25 small laboratory male BALB/c mice were selected randomly and after creating a 5 mm wound on the back of their neck, they were treated with doses of 2.5, 10, and 40 mg/kg body weight, After sampling from the healed wound in 9th day, histopathological studies and the expression of PDGF-ß gene were performed by Real-time PCR method.RESULTS:
The findings of the present study showed that royal jelly caused a significant increase in PDGF-ß (10.99 times) compared to the healthy group. Also, royal jelly increased the formation of covering tissue or epithelium, the synthesis of collagen, the presence of inflammatory cells, and the formation of new blood vessels.CONCLUSION:
The oral treatment of royal jelly is probably effective in skin wound healing by changing the expression of PDGF-ß.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Apiterapia
Asunto principal:
Cicatrización de Heridas
/
Factor de Crecimiento Derivado de Plaquetas
Idioma:
En
Revista:
J Tissue Viability
Año:
2023
Tipo del documento:
Article