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Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis.
Zhang, Dingkun; Deng, Xuan; Li, Mengqi; Qiu, Min; Zhang, Yifan; Li, Gefei; Jiang, Yurou; Tan, Peng; Fan, Sanhu; Zheng, Youde; Lin, Junzhi; Han, Li; Huang, Haozhou.
Afiliación
  • Zhang D; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCM, Chengdu, 611137, China.
  • Deng X; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCM, Chengdu, 611137, China.
  • Li M; Pharmacy Department, Sichuan Nursing Vocational College, Chengdu, 610100, China.
  • Qiu M; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCM, Chengdu, 611137, China.
  • Zhang Y; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCM, Chengdu, 611137, China.
  • Li G; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCM, Chengdu, 611137, China.
  • Jiang Y; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCM, Chengdu, 611137, China.
  • Tan P; State Key Laboratory of Quality Evaluation of Traditional Chinese Medicine, Sichuan Academy of Traditional Chinese Medicine, Chengdu, 610041, China.
  • Fan S; Sanajon Pharmaceutical Group, Chengdu, 610000, China.
  • Zheng Y; Sanajon Pharmaceutical Group, Chengdu, 610000, China.
  • Lin J; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, People's Republic of China. 582097013@qq.com.
  • Han L; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCM, Chengdu, 611137, China. hanliyx@163.com.
  • Huang H; State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. 1539889839@qq.com.
Chin Med ; 18(1): 127, 2023 Oct 01.
Article en En | MEDLINE | ID: mdl-37779204
Polyphenols are the main component of Phyllanthus emblica (PE). However, polyphenols are so easy to transform that it is unknown that how drying methods driven by heating affect the anti-fatigue effect of PE. This manuscript investigated the effects of five drying methods on the chemical composition transformation and anti-fatigue of PE, and discussed the action mechanism. The results suggested that the anti-fatigue effect of PE with hot-air-dried at 100 °C was the best, which was as 1.63 times as that with freeze-drying. Ellagic acid (EA) may be a key component of PE in anti-fatigue, and its mechanism of action may be related to regulating intestinal microbiota, protecting mitochondria, and regulating energy metabolism. This study first revealed the thermal transformation of polyphenols in PE, found the most effective strategy for enhancing the anti-fatigue function, and explores its action mechanism.
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Plantas_medicinales Idioma: En Revista: Chin Med Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Plantas_medicinales Idioma: En Revista: Chin Med Año: 2023 Tipo del documento: Article País de afiliación: China