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Effects of prenatal docosahexaenoic acid supplementation on offspring cardiometabolic health at 11 years differs by maternal single nucleotide polymorphism rs174602: follow-up of a randomized controlled trial in Mexico.
Wimalasena, Sonia Tandon; Ramírez-Silva, Claudia Ivonne; Gonzalez Casanova, Ines; Stein, Aryeh D; Sun, Yan V; Rivera, Juan A; Demmelmair, Hans; Koletzko, Berthold; Ramakrishnan, Usha.
Afiliación
  • Wimalasena ST; Doctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, United States.
  • Ramírez-Silva CI; National Institute of Public Health, Cuernavaca, Mexico.
  • Gonzalez Casanova I; Indiana University Bloomington School of Public Health, Bloomington, IN, United States.
  • Stein AD; Doctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, United States; Hubert Department of Global Health, Emory University, Atlanta, GA, United States.
  • Sun YV; Department of Epidemiology, Emory University, Atlanta, GA, United States.
  • Rivera JA; National Institute of Public Health, Cuernavaca, Mexico.
  • Demmelmair H; LMU-Ludwig Maximilians Universität, Department of Pediatrics, LMU University Hospitals, Munich, Germany.
  • Koletzko B; LMU-Ludwig Maximilians Universität, Department of Pediatrics, LMU University Hospitals, Munich, Germany.
  • Ramakrishnan U; Doctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, United States; Hubert Department of Global Health, Emory University, Atlanta, GA, United States. Electronic address: ramakr@emory.edu.
Am J Clin Nutr ; 118(6): 1123-1132, 2023 12.
Article en En | MEDLINE | ID: mdl-37839707
ABSTRACT

BACKGROUND:

There is limited evidence regarding long-term effects of prenatal docosahexaenoic acid (DHA) supplementation on offspring cardiometabolic health (CMH). Inconsistent results may be attributable to variants of fatty acid desaturase (FADS) genes.

OBJECTIVE:

We aimed to evaluate the effect of prenatal DHA supplementation on offspring CMH and investigate effect modification by maternal FADS2 single nucleotide polymorphism (SNP) rs174602.

METHODS:

We used follow-up data from a double-blind, randomized controlled trial in Mexico in which pregnant females received 400 mg/d of algal DHA or placebo from midgestation until delivery. The study sample included 314 offspring with data at age 11 y and maternal FADS genetic data (DHA n = 160; Placebo n = 154). We derived a Metabolic Syndrome (MetS) score from body mass index, HDL, triglycerides, fasting glucose concentrations, and systolic blood pressure. Generalized linear models were used to evaluate the effect of the intervention on offspring MetS score and test interactions between treatment group and genotype, adjusting for maternal, offspring, and household factors.

RESULTS:

Offspring MetS score did not differ significantly by treatment group. We observed evidence of effect modification by maternal SNP rs174602 (P = 0.001); offspring of maternal TT genotype who received DHA had lower MetS score relative to the placebo group (DHA (mean ± standard error of the mean (SEM)) -0.21 ± 0.11, n = 21; Placebo 0.05 ± 0.11, n = 23; Δ= -0.26 (95% CI -0.55, 0.04), P = 0.09); among CC maternal genotype carriers, offspring of mothers who received DHA had higher MetS score (0.18 ± 0.06, n = 62) relative to the placebo group (-0.05 ± 0.06, n = 65, Δ=0.24 (0.06, 0.41), P < 0.01).

CONCLUSION:

The effect of prenatal DHA supplementation on offspring MetS score differed by maternal FADS SNP rs174602. These findings further support incorporating genetic analysis of FADS polymorphisms in DHA supplementation trials. CLINICAL TRIAL DETAILS This trial was registered at clinicaltrials.gov as NCT00646360.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Ácidos Docosahexaenoicos País/Región como asunto: Mexico Idioma: En Revista: Am J Clin Nutr Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Ácidos Docosahexaenoicos País/Región como asunto: Mexico Idioma: En Revista: Am J Clin Nutr Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos