Selenium alleviates modafinil-induced neurobehavioral toxicity in rat via PI3K/Akt/mTOR/GSK3B signaling pathway and suppression of oxidative stress and apoptosis: in vivo and in silico study.

Shehata, Shaimaa A; Kolieb, Eman; Ali, Dina A; Maher, Shymaa Ahmed; Korayem, Horeya Erfan; Ibrahim, Mahrous A; Nafie, Mohamed S; Ameen, Shimaa H

Shehata, Shaimaa A; Kolieb, Eman; Ali, Dina A; Maher, Shymaa Ahmed; Korayem, Horeya Erfan; Ibrahim, Mahrous A; Nafie, Mohamed S; Ameen, Shimaa H.

Afiliación

Shehata SA; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Kolieb E; Physiology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Ali DA; Clinical Pharmacology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Maher SA; Center of Excellence in Molecular & Cellular Medicine, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Korayem HE; Center of Excellence in Molecular & Cellular Medicine, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Ibrahim MA; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Nafie MS; Histology and Cell Biology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Ameen SH; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt. mabdulbaset@ju.edu.sa.

Environ Sci Pollut Res Int ; 31(1): 458-480, 2024 Jan.

Article en En | MEDLINE | ID: mdl-38015391

Asunto(s)

Glucógeno Sintasa Quinasa 3 beta; Selenio; Humanos; Ratas; Masculino; Animales; Selenio/farmacología; Proteínas Proto-Oncogénicas c-akt/metabolismo; Antioxidantes/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Modafinilo/farmacología; Orexinas/metabolismo; Orexinas/farmacología; Simulación del Acoplamiento Molecular; Ratas Wistar; Transducción de Señal; Serina-Treonina Quinasas TOR/metabolismo; Estrés Oxidativo; Inflamación; Apoptosis; Neurotransmisores

Palabras clave

Apoptosis; Misuse; Neurobehavioral changes; Neurotoxicity; Oxidative stress; Pharmaceutical cognitive enhancers

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Texto completo: 1 Bases de datos: MEDLINE Medicinas Complementárias: Homeopatia Asunto principal: Selenio / Glucógeno Sintasa Quinasa 3 beta Idioma: En Revista: Environ Sci Pollut Res Int Año: 2024 Tipo del documento: Article País de afiliación: Egipto

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