Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1&#945; signaling pathway.

Cheng, Long; Shi, Lu; He, Changhao; Wang, Chen; Lv, Yinglan; Li, Huimin; An, Yongcheng; Duan, Yuhui; Dai, Hongyu; Zhang, Huilin; Huang, Yan; Fu, Wanxin; Sun, Weiguang; Zhao, Baosheng

Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway.

Cheng, Long; Shi, Lu; He, Changhao; Wang, Chen; Lv, Yinglan; Li, Huimin; An, Yongcheng; Duan, Yuhui; Dai, Hongyu; Zhang, Huilin; Huang, Yan; Fu, Wanxin; Sun, Weiguang; Zhao, Baosheng.

Afiliación

Cheng L; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China; Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang 110122, China.
Shi L; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
He C; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Wang C; College of Life Sciences, Beijing University of Chinese Medicine, Beijing 102488, China.
Lv Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Li H; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
An Y; College of Life Sciences, Beijing University of Chinese Medicine, Beijing 102488, China.
Duan Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Dai H; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Zhang H; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Huang Y; College of Life Sciences, Beijing University of Chinese Medicine, Beijing 102488, China.
Fu W; College of Life Sciences, Beijing University of Chinese Medicine, Beijing 102488, China.
Sun W; GuangZhou Baiyunshan Xingqun Pharmaceutical Co., Ltd., Guangzhou 510288, China. Electronic address: suntcm@163.com.
Zhao B; Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: zhaobs1973@163.com.

Chin J Nat Med ; 21(11): 812-829, 2023 Nov.

Article en En | MEDLINE | ID: mdl-38035937

Asunto(s)

Diabetes Mellitus Tipo 2; Morus; Ratones; Animales; Tejido Adiposo Pardo; Sirtuina 1/genética; Sirtuina 1/metabolismo; Sirtuina 1/farmacología; Diabetes Mellitus Tipo 2/tratamiento farmacológico; Diabetes Mellitus Tipo 2/metabolismo; Proteínas Quinasas Activadas por AMP/genética; Proteínas Quinasas Activadas por AMP/metabolismo; Morus/metabolismo; Flavonoides/farmacología; Flavonoides/metabolismo; Estudios Prospectivos; Transducción de Señal; Tejido Adiposo Blanco; Hojas de la Planta; Proteína Desacopladora 1/metabolismo; Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/metabolismo

Palabras clave

AMPK/SIRT1/PGC-1α; Brown adipose tissue; Browning of white adipose tissue; Mulberry leaf flavonoids; Type 2 diabetes

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Morus / Diabetes Mellitus Tipo 2 Idioma: En Revista: Chin J Nat Med Año: 2023 Tipo del documento: Article País de afiliación: China

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