Ameliorative effects of Modified Huangqi Chifeng decoction on podocyte injury via autophagy mediated by PI3K/AKT/mTOR and AMPK/mTOR pathways.

Zhao, Mingming; Yin, Yundong; Yang, Bin; Chang, Meiying; Ma, Sijia; Shi, Xiujie; Li, Qi; Li, Peng; Zhang, Yu

Zhao, Mingming; Yin, Yundong; Yang, Bin; Chang, Meiying; Ma, Sijia; Shi, Xiujie; Li, Qi; Li, Peng; Zhang, Yu.

Afiliación

Zhao M; Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: XMingYX@163.com.
Yin Y; Postdoctoral Research Station, China Academy of Chinese Medical Sciences, Beijing, 100700, China; Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: yyd0030@163.com.
Yang B; Department of Pathology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: yangbin555@126.com.
Chang M; Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: 1551527727@qq.com.
Ma S; Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: masijia96@163.com.
Shi X; Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: sxiujie802@163.com.
Li Q; Department of Clinical Laboratory, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: yourslq@126.com.
Li P; Institute of Basic Medical Sciences, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, 100091, China; Key Laboratory of Pharmacology of Chinese Materia Medica of Beijing, Beijing, 100091, China. Electronic address: pengli1972cn@126.com.
Zhang Y; Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China; Xin-Huangpu Joint Innovation Institute of Chinese Medicine, Guangzhou, 510000, China. Electronic address: zhangyu8225@126.com.

J Ethnopharmacol ; 321: 117520, 2024 Mar 01.

Article en En | MEDLINE | ID: mdl-38042389

Asunto(s)

Enfermedades Renales; Podocitos; Ratas; Animales; Proteínas Proto-Oncogénicas c-akt/metabolismo; Fosfatidilinositol 3-Quinasa/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Quinasas Activadas por AMP/metabolismo; Ratas Sprague-Dawley; Serina-Treonina Quinasas TOR/metabolismo; Enfermedades Renales/inducido químicamente; Enfermedades Renales/tratamiento farmacológico; Enfermedades Renales/metabolismo; Proteinuria/inducido químicamente; Proteinuria/tratamiento farmacológico; Proteinuria/metabolismo; Autofagia; Doxorrubicina/farmacología; Mamíferos/metabolismo

Palabras clave

AMPK/mTOR signal pathway; Autophagy; Chronic kidney disease; Modified Huangqi Chifeng decoction; PI3K/AKT/mTOR signal pathway; Podocytes

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Podocitos / Enfermedades Renales Idioma: En Revista: J Ethnopharmacol Año: 2024 Tipo del documento: Article