In vitro inhibition of six active sesquiterpenoids in zedoary turmeric oil on human liver cytochrome P450 enzymes.

Liu, Suyan; Zhao, Yong; Tang, Xuan; Yang, Junling; Pan, Chen; Liu, Chenyue; Han, Jiayin; Li, Chunying; Yi, Yan; Li, Yingfei; Cheng, Jintang; Zhang, Yushi; Wang, Lianmei; Tian, Jingzhuo; Wang, Yuan; Wang, Liping; Liang, Aihua

Liu, Suyan; Zhao, Yong; Tang, Xuan; Yang, Junling; Pan, Chen; Liu, Chenyue; Han, Jiayin; Li, Chunying; Yi, Yan; Li, Yingfei; Cheng, Jintang; Zhang, Yushi; Wang, Lianmei; Tian, Jingzhuo; Wang, Yuan; Wang, Liping; Liang, Aihua.

Afiliación

Liu S; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Zhao Y; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Tang X; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Yang J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China.
Pan C; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Liu C; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Han J; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Li C; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Yi Y; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Li Y; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Cheng J; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Zhang Y; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Wang L; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Tian J; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Wang Y; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Wang L; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China.
Liang A; State Key Laboratory of Innovative Natural Medicine and TCM Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China. Electronic address: ahliang@icmm.ac.cn.

J Ethnopharmacol ; 322: 117588, 2024 Mar 25.

Article en En | MEDLINE | ID: mdl-38104879

Asunto(s)

Curcuma; Sesquiterpenos; Humanos; Sistema Enzimático del Citocromo P-450; Hígado; Sesquiterpenos/farmacología; Microsomas Hepáticos; Citocromo P-450 CYP3A

Palabras clave

CYP450s; Drug-drug interactions; Inhibition; Mechanism; Sesquiterpenoids

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sesquiterpenos / Curcuma Idioma: En Revista: J Ethnopharmacol Año: 2024 Tipo del documento: Article