Effect of daily zinc supplementation for 12 weeks on serum thyroid auto-antibody levels in children and adolescents with autoimmune thyroiditis - a randomized controlled trial.
J Pediatr Endocrinol Metab
; 37(2): 137-143, 2024 Feb 26.
Article
en En
| MEDLINE
| ID: mdl-38154030
ABSTRACT
OBJECTIVES:
To assess the effect of daily zinc supplementation for 12 weeks on thyroid auto-antibodies - thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), and oxidative stress in children with autoimmune thyroid disease (AITD) compared to standard therapy.METHODS:
This open-labeled, parallel, randomized controlled trial was done in a tertiary care teaching institute in south India. Children aged 3-18 years with AITD were randomized to receive 25â¯mg elemental zinc daily for 12 weeks or standard therapy alone. The change in thyroid function tests (thyroid stimulating hormone, free T3, free T4), thyroid auto-antibody (TPOAb, TgAb) titers, oxidative stress markers (glutathione peroxidase, malondialdehyde, superoxide dismutase, and total antioxidant capacity) were compared.RESULTS:
Forty children, 20 in each arm, were recruited in the study. We observed a female-to-male ratio of 71. Median duration of disease was 2 (0.25, 4.25) years. A total of 37 (92.5â¯%) children were hypothyroid, two hyperthyroid, and one euthyroid at enrolment. A total of 13 children (32.5â¯%) had associated co-morbidities, most commonly type 1 diabetes mellitus and systemic lupus erythematosus, three (7.5â¯%) each. We did not find any significant change in thyroid function tests, thyroid auto-antibody titers, and oxidative stress markers. However, the requirement of levothyroxine dose was significantly increased in the control arm, compared to the zinc group (p=0.03). Only four (20â¯%) children had minor adverse effects like nausea, metallic taste, and body ache.CONCLUSIONS:
Zinc supplementation did not have any effect on thyroid auto-antibodies and oxidative stress. Zinc-supplemented children did not require escalation in levothyroxine dose.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Tiroiditis Autoinmune
/
Enfermedad de Hashimoto
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Año:
2024
Tipo del documento:
Article
País de afiliación:
India