Gastrodin: a comprehensive pharmacological review.
Naunyn Schmiedebergs Arch Pharmacol
; 397(6): 3781-3802, 2024 06.
Article
en En
| MEDLINE
| ID: mdl-38165423
ABSTRACT
Tianma is the dried tuber of Gastrodia elata Blume (G. elata), which is frequently utilized in clinical practice as a traditional Chinese medicine. Gastrodin (GAS) is the main active ingredient of Tianma, which has good pharmacological activity. Therefore, for the first time, this review focused on the extraction, synthesis, pharmacological effects, and derivatives of GAS and to investigate additional development options for GAS. The use of microorganisms to create GAS is a promising method. GAS has good efficacy in the treatment of neurological diseases, cardiovascular diseases, endocrine diseases, and liver diseases. GAS has significant anti-inflammatory, antioxidant, neuroprotective, vascular protective, blood sugar lowering, lipid-regulating, analgesic, anticancer, and antiviral effects. The mechanism involves various signaling pathways such as Nrf2, NF-κB, PI3K/AKT, and AMPK. In addition, the derivatives of GAS and biomaterials synthesized by GAS and PU suggested a broader application of GAS. The research on GAS is thoroughly summarized in this paper, which has useful applications for tackling a variety of disorders and exhibits good development value.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Asunto principal:
Alcoholes Bencílicos
/
Glucósidos
Idioma:
En
Revista:
Naunyn Schmiedebergs Arch Pharmacol
/
Naunyn-Schmiedeberg's arch. pharmacol. (Internet)
/
Naunyn-Schmiedeberg's archives of pharmacology (Internet)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China