Molybdenum-Copper Antagonism In Metalloenzymes And Anti-Copper Therapy.
Chembiochem
; 25(6): e202300679, 2024 03 15.
Article
en En
| MEDLINE
| ID: mdl-38205937
ABSTRACT
The connection between 3d (Cu) and 4d (Mo) via the "Mo-S-Cu" unit is called Mo-Cu antagonism. Biology offers case studies of such interactions in metalloproteins such as Mo/Cu-CO Dehydrogenases (Mo/Cu-CODH), and Mo/Cu Orange Protein (Mo/Cu-ORP). The CODH significantly maintains the CO level in the atmosphere below the toxic level by converting it to non-toxic CO2 for respiring organisms. Several models were synthesized to understand the structure-function relationship of these native enzymes. However, this interaction was first observed in ruminants, and they convert molybdate (MoO4 2- ) into tetrathiomolybdate (MoS4 2- ; TTM), reacting with cellular Cu to yield biological unavailable Mo/S/Cu cluster, then developing Cu-deficiency diseases. These findings inspire the use of TTM as a Cu-sequester drug, especially for treating Cu-dependent human diseases such as Wilson diseases (WD) and cancer. It is well known that a balanced Cu homeostasis is essential for a wide range of biological processes, but negative consequence leads to cell toxicity. Therefore, this review aims to connect the Mo-Cu antagonism in metalloproteins and anti-copper therapy.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cobre
/
Metaloproteínas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Chembiochem
Año:
2024
Tipo del documento:
Article
País de afiliación:
India