Protocol for producing phosphoramidate using phosphorus fluoride exchange click chemistry.
STAR Protoc
; 5(1): 102824, 2024 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-38217854
ABSTRACT
Phosphorus fluoride exchange (PFEx) is a catalytic click reaction that involves exchanging high oxidation state P-F bonds with alcohol and amine nucleophiles, reliably yielding P-O- and P-N-linked compounds. Here, we describe steps for preparing a phosphoramidic difluoride and performing two sequential PFEx reactions to yield a phosphoramidate through careful catalyst selection. We then detail procedures for handling and quenching potentially toxic P-F-containing compounds to ensure user safety when conducting PFEx reactions. For complete details on the use and execution of this protocol, please refer to Sun et al.1.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Química Clic
/
Fluoruros
/
Amidas
Idioma:
En
Revista:
STAR Protoc
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos