Causal oscillations in the visual thalamo-cortical network in sustained attention in ferrets.
Curr Biol
; 34(4): 727-739.e5, 2024 02 26.
Article
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| MEDLINE
| ID: mdl-38262418
ABSTRACT
Sustained visual attention allows us to process and react to unpredictable, behaviorally relevant sensory input. Sustained attention engages communication between the higher-order visual thalamus and its connected cortical regions. However, it remains unclear whether there is a causal relationship between oscillatory circuit dynamics and attentional behavior in these thalamo-cortical circuits. By using rhythmic optogenetic stimulation in the ferret, we provide causal evidence that higher-order visual thalamus coordinates thalamo-cortical and cortico-cortical functional connectivity during sustained attention via spike-field phase locking. Increasing theta but not alpha power in the thalamus improved accuracy and reduced omission rates in a sustained attention task. Further, the enhancement of effective connectivity by stimulation was correlated with improved behavioral performance. Our work demonstrates a potential circuit-level causal mechanism for how the higher-order visual thalamus modulates cortical communication through rhythmic synchronization during sustained attention.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Corteza Visual
/
Hurones
Idioma:
En
Revista:
Curr Biol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos