Cadmium as a male reproductive toxicant and natural and non-natural ways to tackle it: a review.
Environ Sci Pollut Res Int
; 31(12): 18340-18361, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38349491
ABSTRACT
Cadmium (Cd) is a naturally occurring environmental pollutant, a toxic substance that causes oxidative stress. According to epidemiological studies, the data suggested that environmental and occupational Cd exposure may be related to several diseases and severe testicular damage. However, studies are going on to explore the mechanism of Cd-induced male reproductive toxicity and its treatment strategies. Currently, researchers are focusing on naturally occurring bioactive compounds, plant extracts, and biochemical, which have better efficacy, less toxicity, and high bioavailability. This review focuses on the mechanistic effect of Cd on testicular toxicity and different categories of compounds having a beneficial impact on Cd-induced male reproductive toxicity. Some potent bioactive antioxidants are quercetin, caffeic acid phenethyl ester, cyanidin-3-O-glucoside, curcumin, and silymarin. In comparison, plant extracts are Costus afer leaf methanol extract, methanol root extract of Carpolobia lutea, red carrot methanolic extract, Panax ginseng extract, and biochemicals including melatonin, progesterone, glutamine, L-carnitine, and selenium. Advanced and more detailed studies are needed on these compounds to explore their mechanism in attenuating Cd-induced testicular toxicity and can be potential therapeutics in the future.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cadmio
/
Intoxicación por Cadmio
Idioma:
En
Revista:
Environ Sci Pollut Res Int
Año:
2024
Tipo del documento:
Article
País de afiliación:
India