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Polyacetylenes from Saposhnikovia divaricata and their anticancer activity.
Sun, Yan; Liu, Yan; Jiang, Peng; Wang, Si-Yi; Pan, Juan; Guan, Wei; Wang, Yu-Xuan; Kuang, Hai-Xue; Wang, Yan-Hong; Yang, Bing-You.
Afiliación
  • Sun Y; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China.
  • Liu Y; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China.
  • Jiang P; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China.
  • Wang SY; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China.
  • Pan J; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China.
  • Guan W; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China.
  • Wang YX; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China.
  • Kuang HX; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China.
  • Wang YH; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China.
  • Yang BY; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China. Electronic address: ybywater@163.com.
Fitoterapia ; 174: 105876, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38431027
ABSTRACT
Nine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4+ probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD. Also, all compounds were evaluated for cytotoxicity against two human cancer cell lines (A549, HEPG2) in vitro, compound 9 showed moderate inhibitory effect with an IC50 value of 11.66 µM against HEPG2.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Apiaceae / Poliinos Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Apiaceae / Poliinos Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article