Alliaxylines A-E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss.
J Nat Med
; 78(3): 558-567, 2024 Jun.
Article
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| MEDLINE
| ID: mdl-38517622
ABSTRACT
A total of five new mexicanolides (1-5), namely alliaxylines A-E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI-MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound 2 was the most potent against the two tested cells, with IC50 values of 34.95 ± 0.21 and 44.39 ± 1.03 µM.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Meliaceae
/
Corteza de la Planta
/
Limoninas
País/Región como asunto:
Mexico
Idioma:
En
Revista:
J Nat Med
Año:
2024
Tipo del documento:
Article
País de afiliación:
Indonesia