Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression.
Fitoterapia
; 175: 105951, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38583637
ABSTRACT
Four undescribed amide alkaloids hongkongensines A-C and 1-(1-oxo-6-hydroxy-2E,4E-dodecadienyl)-piperidine, five known amide alkaloids, and three known neolignans were isolated from the aerial part of Piper hongkongense. The planar structures of these compounds were determined by detailed analyses of HR-ESI-MS and NMR data. The absolute configurations of hongkongensines A-C were elucidated by single-crystal X-ray diffraction analysis and ECD calculations. Moreover, the inhibitory activities of PCSK9 expression in vitro for all compounds were assessed by PCSK9 AlphaLISA screening. Kadsurenone (10) displayed a significant inhibitory activity at 5 µM with an inhibition rate of 51.98%, compared with 55.55% of berberine (BBR 5 µM).
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Lignanos
/
Piper
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Componentes Aéreos de las Plantas
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Alcaloides
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Fitoquímicos
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Inhibidores de PCSK9
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Año:
2024
Tipo del documento:
Article
País de afiliación:
China