Experimental study in rabbits of the antishock effect of anisodamine (654-2), and its mechanism of action.
Resuscitation
; 10(3): 173-84, 1983 Feb.
Article
en En
| MEDLINE
| ID: mdl-6302797
ABSTRACT
The antishock effect of anisodamine (654-2) was observed in different kinds of experimental shock in groups of rabbits--due to late hemorrhage, superior mesenteric artery occlusion, and septic shock from peritonitis. The drug 654-2 significantly alleviated the progress of shock and increased the survival rate of the animals. The therapeutic effect of 654-2 was much better than that of other vasoactive drugs commonly used, such as norepinephrine, phenoxybenzamine, dopamine, and aramine. The antishock mechanism of 654-2 is probably partly due to its protective action on intestinal shock in preventing its effects becoming irreversible. The antishock action of 654-2 both by basic research workers and clinicians merits further study.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Plantas_medicinales
Asunto principal:
Choque Séptico
/
Alcaloides Solanáceos
/
Vasoconstrictores
/
Presión Sanguínea
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Resuscitation
Año:
1983
Tipo del documento:
Article