Ruthenium-97 DTPA: a new radiopharmaceutical for cisternography.
J Nucl Med
; 22(3): 269-73, 1981 Mar.
Article
en En
| MEDLINE
| ID: mdl-7205369
ABSTRACT
Ruthenium-97 DTPA (diethylenetriamine penta-acetic acid) was evaluated for its possible use as a cerebrospinal fluid imaging agent. Ru-97 has favorable physical properties that are highly suitable for imaging decay by electron capture; gamma energy = 216 keV, 85%; T 1/2 = 2.9 days. Dogs were injected with 0.4 mCi Ru-97 DTPA or In-111 DTPA into the cisterna magna. The movement of the agents was monitored with a camera interfaced to a computer, or with a dual-probe system placed over the head and urinary bladder. In addition, blood and urine samples were collected at fixed intervals for 6 hr. High-quality images were obtained up to 48 hr after injection. The results show that the kinetics and excretion of Ru-97 DTPA are similar to those of In-111 DTPA. Radiation dose for identical activities is twice as high for In-111, in part because of greater abundance of the low-energy electron emission of In-111.
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Bases de datos:
MEDLINE
Asunto principal:
Rutenio
/
Encéfalo
/
Cisterna Magna
/
Ácido Pentético
Idioma:
En
Revista:
J Nucl Med
Año:
1981
Tipo del documento:
Article