Clinical aspects of parathyroid hypertensive factor.
J Cardiovasc Pharmacol
; 23 Suppl 2: S23-6, 1994.
Article
en En
| MEDLINE
| ID: mdl-7518541
ABSTRACT
To determine the clinical significance of parathyroid hypertensive factor (PHF), physiological studies previously performed in animal models of hypertension were parallelled by human studies. These studies revealed that PHF-like activity is present in human hypertension, where it correlates with the salt-sensitive, low-renin state. As in spontaneously hypertensive rats, both supplemental calcium and calcium-channel blockers appear to be useful in the treatment of PHF-related hypertension. In primary hyperparathyroid patients, PHF presence is linked with the presence of hypertension. Postparathyroidectomy blood pressure falls in parallel with PHF levels. These preliminary human studies suggest that PHF may be a useful marker in the treatment of hypertension.
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Bases de datos:
MEDLINE
Asunto principal:
Factores Biológicos
/
Hipertensión
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Cardiovasc Pharmacol
Año:
1994
Tipo del documento:
Article
País de afiliación:
Canadá