Effects of magnesium supplementation in a porcine model of myocardial ischemia and reperfusion.
J Cardiovasc Pharmacol
; 24(4): 603-11, 1994 Oct.
Article
en En
| MEDLINE
| ID: mdl-7528843
ABSTRACT
We tested the hypothesis that acute, intravenous (i.v.) magnesium (Mg2+) supplementation would protect against myocardial stunning in an in situ swine model of regional ischemia and reperfusion and that a concomitant inhibitory effect on platelet aggregation would be elicited. An open-chest model was used, with transient occlusion of the left anterior descending coronary artery (LAD) for 8 min. Regional contractile function was assessed by measuring wall thickening fraction with epicardial Doppler crystals. One control group (n = 6) and two treatment groups were studied group I (n = 6) received 750 mg MgSO4 before occlusion; group II (n = 6) received 1 g MgSO4 after the occlusion. Both protocols produced significant hypermagnesemia. In group I, platelet aggregation was measured before and after Mg2+ treatment using platelet-rich plasma (PRP) and various agonists (ADP 5 and 10 mM and collagen 1 mg/ml). As compared with controls, both treatment groups experienced significantly less postischemic dysfunction, with systolic function returning more quickly to baseline. Furthermore, platelet aggregation was significantly decreased immediately after Mg2+ infusion. Inhibition of platelet aggregation induced by Mg2+ treatment occurs concomitantly with significant amelioration of postischemic myocardial dysfunction.
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Bases de datos:
MEDLINE
Asunto principal:
Isquemia Miocárdica
/
Aturdimiento Miocárdico
/
Magnesio
Tipo de estudio:
Guideline
Idioma:
En
Revista:
J Cardiovasc Pharmacol
Año:
1994
Tipo del documento:
Article