Association of the antibody response to hemocyanin with behavior in mice bred for high or low antibody responsiveness.
Behav Neurosci
; 108(6): 1172-8, 1994 Dec.
Article
en En
| MEDLINE
| ID: mdl-7893409
ABSTRACT
Researchers attempted to find a genetic correlation between the antibody response and some behaviors by comparing the behavioral profile of good antibody-producing mice (Biozzi's H mice) with that of bad antibody producers (Biozzi's L mice). The behavioral tests used were 2 open fields, a light-darkness test, and reaction to capture; the antigen was keyhole limpet hemocyanin, and blood levels of immunoglobulin (Classes IgM and IgG) antibodies to hemocyanin were measured by diffusion-in-gel-enzyme-linked immunosorbent assay. H and L mice differed in the magnitude of the antibody response (H > L), in reaction to capture (L > H), and in rearing in 1 of the open fields (L > H). Yet the level of IgM or IgG antibodies was uncorrelated with those behaviors in the (H x L) F2 hybrids and in outbred CD1 mice. Thus, the behavioral differences between H and L mice are not due to the antibody response genes but to other genes fixed during selection for antibody responsiveness.
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Bases de datos:
MEDLINE
Asunto principal:
Nivel de Alerta
/
Conducta Animal
/
Hemocianinas
/
Genes MHC Clase II
/
Formación de Anticuerpos
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Behav Neurosci
Año:
1994
Tipo del documento:
Article
País de afiliación:
España