In vitro and in vivo effects of photodynamic therapy in cutaneous T cell lymphoma.
Acta Derm Venereol
; 74(3): 201-5, 1994 May.
Article
en En
| MEDLINE
| ID: mdl-7915462
ABSTRACT
Photodynamic therapy consists of the combination of photosensitizers absorbing light in the visible spectral region and irradiation with light of corresponding wavelengths. We analysed its effects in comparison to PUVA treatment on cell lines MyLA and HuT78, established from patients with cutaneous T cell lymphomas. Proliferation was reduced to 50% by exposure to 7.5 J/cm2 UV-A (= ED50). This effect was increased more than 10-fold in the presence of 10 micrograms/ml 8-methoxypsoralen. The ED50 for photodynamic therapy using 630 nm light emitted by a dye laser and 10 micrograms/ml Photosan-3 was found to be about 1 J/cm2. In vivo fluorescence recordings during topical photodynamic therapy of mycosis fungoides lesions showed photo-bleaching and thus documented the triggering of photochemical reactions. Our observations document the capability of photodynamic therapy to inhibit proliferation of transformed T cells similar to PUVA, pointing out its potential in the treatment of cutaneous T cell lymphomas.
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Bases de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
/
Neoplasias Cutáneas
/
Linfoma Cutáneo de Células T
Idioma:
En
Revista:
Acta Derm Venereol
Año:
1994
Tipo del documento:
Article
País de afiliación:
Alemania