[Pharmacological action of 101-B hair regeneration extract on skin and hair in experimental animals].

ABSTRACT

Pharmacological action of 101-B hair regeneration extract (101-B) on skin and hair was studied in experimental animals. The results were as follows (1) In normal rats, guinea pigs and rabbits the weight of regrown hairs in shaved area in 101-B group was significantly heavier than that in alcohol group. (2) Hair loss induced by oral administration of thallium carbonate 2 mg/kg every other day for 10 times was obviously prevented by topical treatment of 101-B. (3) Itching threshold to histamine or papain in guinea pig was elevated after using of 101-B topically. (4) The diameter of skin ulcer caused by intradermal injection of adriamycin in rats was diminished in 101-B group. (5) Observation in skin microcirculation in mice indicated that both normal skin microcirculation and disturbed microcirculation induced by endotoxin were improved with administration of 101-B. Above experimental results provided preliminary evidence for clinical use of 101-B.