Effect of three Japanese kampo medicines on platelet activation by monoclonal anti-platelet membrane glycoprotein antibodies.
Am J Chin Med
; 22(1): 71-6, 1994.
Article
en En
| MEDLINE
| ID: mdl-8030621
We studied the effect of three Japanese kampo medicines on platelet activation by an anti-CD9 monoclonal antibody (NNKY1-19) and an anti-human Fc gamma receptor II monoclonal antibody (NNKY3-2). Sho-saiko-to (TJ-9) and Sairei-to (TJ-114) partially suppressed platelet aggregation induced by NNKY1-19, while Juzen-taiho-to (TJ-48) suppressed aggregation induced by NNKY3-2. TJ-9 and TJ-114 also suppressed collagen-induced aggregation, but TJ-48 did not. Flow cytometry showed that the three medicines did not affect antibody binding to the platelets. Thus, all three kampo medicines suppressed platelet activation by anti-platelet glycoprotein antibodies without inhibiting antibody binding.
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Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
/
Medicina_japonesa
Asunto principal:
Medicamentos Herbarios Chinos
/
Glicoproteínas de Membrana Plaquetaria
/
Activación Plaquetaria
/
Antígenos de Plaqueta Humana
/
Anticuerpos Monoclonales
Idioma:
En
Revista:
Am J Chin Med
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón