Observations on the effect of areca nut extracts on oral fibroblast proliferation.
J Oral Pathol Med
; 23(4): 145-8, 1994 Apr.
Article
en En
| MEDLINE
| ID: mdl-8046651
ABSTRACT
The effects of aqueous extracts of raw, baked and boiled areca nuts were tested on cultured human buccal mucosa fibroblasts. Cells were exposed to extract concentrations of 0, 50, 100, 150, 300 and 500 micrograms/ml. The arecoline and arecaidine content was determined in the extracts with HPLC and raw nut contained 5.5% m/m, baked nut 6.6% m/m and boiled nut 7.1% m/m. Extract concentrations of 50 to 150 micrograms/ml inhibited cell growth in a concentration-dependent manner but did not lead to total cell death during a 7 day period. However, total cell death did occur with concentrations of 300 and 500 micrograms/ml. It is concluded that areca nut extract is toxic to cultured fibroblasts and inhibits their proliferation in a concentration-dependent manner.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Areca
/
Plantas Medicinales
/
Extractos Vegetales
/
Mucosa Bucal
Idioma:
En
Revista:
J Oral Pathol Med
Año:
1994
Tipo del documento:
Article
País de afiliación:
Sudáfrica