Longitudinal (T1) and transverse (T2) relaxation times of tissue water protons in mouse developing sarcoma 180-A: effect of hyperthermia.
Int J Hyperthermia
; 9(6): 811-9, 1993.
Article
en En
| MEDLINE
| ID: mdl-8106822
ABSTRACT
In vitro studies on Swiss mice, inoculated with dead or live sarcoma 180-A ascites cells, were carried out to monitor the changes, if any, in the longitudinal (T1) and transverse (T2) relaxation times of tissue water protons following hyperthermic treatment and subsequent thermotolerance. Both relaxation processes exhibited biexponential relaxation curves. With increasing size of the tumours, the longitudinal relaxation behaviour changed from bi- to mono-exponential. This was not observed for the transverse relaxation phenomenon. Inoculation with either dead or live cells caused an immediate increase in the both relaxation times. In the case of dead cell inoculation, the increase lasted for only 24 h after which the relaxation times became the same as for the uninoculated controls. The transverse relaxation time increased as a result of exposure to hyperthermia. During development of thermotolerance, both the relaxation times decreased.
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Bases de datos:
MEDLINE
Asunto principal:
Sarcoma 180
/
Agua Corporal
/
Hipertermia Inducida
Idioma:
En
Revista:
Int J Hyperthermia
Año:
1993
Tipo del documento:
Article
País de afiliación:
India