Tryptophan depletion in patients with obsessive-compulsive disorder who respond to serotonin reuptake inhibitors.
Arch Gen Psychiatry
; 51(4): 309-17, 1994 Apr.
Article
en En
| MEDLINE
| ID: mdl-8161291
ABSTRACT
METHODS:
The effects of short-term tryptophan depletion were examined in 15 patients with DSM-III-R obsessive-compulsive disorder who had demonstrated symptom reduction following treatment with serotonin reuptake inhibitors. Patients received a 24-hour, low-tryptophan (160-mg/d) diet followed the next morning by a drink of 15 amino acids. A double-blind, placebo-controlled cross-over design was used.RESULTS:
The diet and the amino acid drink reduced free plasma tryptophan levels by a mean of 84% 5 hours later. Short-term tryptophan depletion did not significantly change mean ratings of obsessions and compulsions. In contrast, mean depression ratings were significantly increased with tryptophan depletion compared with the control (tryptophan-supplemented) testing.CONCLUSION:
Maintenance of serotonin reuptake inhibitor-induced improvement of obsessive and compulsive symptoms, unlike remission of depressive symptoms, may not depend on ongoing short-term availability of serotonin.
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Bases de datos:
MEDLINE
Asunto principal:
Triptófano
/
Inhibidores Selectivos de la Recaptación de Serotonina
/
Trastorno Obsesivo Compulsivo
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
Arch Gen Psychiatry
Año:
1994
Tipo del documento:
Article