Protective effect of ginseng saponins against impaired brain growth in neonatal rats exposed to ethanol.
Biol Pharm Bull
; 17(2): 270-4, 1994 Feb.
Article
en En
| MEDLINE
| ID: mdl-8205126
ABSTRACT
This study was performed to determine the active constituents of the root of Panax ginseng C. A. Mayer in the amelioration of ethanol-induced impediment of brain growth in the neonatal stage. To establish an animal model of the brain growth impediment caused by ethanol, ethanol (6 g/kg s.c.) was administered to rat pups on postnatal day 6, which corresponded to the third trimester of pregnancy for humans. Brain weight, especially cerebellar weight, was significantly reduced in the ethanol-exposed pups. In contrast, neither separation from dams nor pentobarbital treatment affected brain weight. A saponin fraction of ginseng extract prevented this ethanol-induced reduction of brain weight. Some ginseng saponins including ginsenosides Rg1, Rb2, Rd, Rf and Re effected stimulated a potent recovery of cerebellum growth in this animal model.
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Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Plantas Medicinales
/
Saponinas
/
Encéfalo
/
Medicamentos Herbarios Chinos
/
Etanol
/
Panax
Idioma:
En
Revista:
Biol Pharm Bull
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón