Hypothalamic norepinephrine depletion inhibits CRF-41 release following neural stimuli.
Neuroreport
; 5(3): 258-60, 1993 Dec 13.
Article
en En
| MEDLINE
| ID: mdl-8298085
ABSTRACT
The effects of depletion of hypothalamic norepinephrine (NE) on median eminence (ME)-corticotropin-releasing factor (CRF-41) content, serum ACTH and corticosterone (CS) levels, following photic and acoustic stimulation, were investigated. While in intact rats these stimuli caused depletion in CRF-41 and a rise in ACTH and CS level, in rats pretreated with 6-hydroxydopamine (6-OHDA), these effects were prevented. This would suggest that the blockage in the release of ME CRF-41 into the portal plasma following neural stimuli in rats with hypothalamic NE depletion, is responsible for the inhibition of the pituitary-adrenocortical response.
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Bases de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Corticotropina
/
Norepinefrina
/
Hipotálamo
/
Neuronas
Idioma:
En
Revista:
Neuroreport
Año:
1993
Tipo del documento:
Article
País de afiliación:
Israel