Effects of ultraviolet-B and PUVA on ornithine decarboxylase activity, DNA synthesis, and protein kinase C activity in mouse skin.
J Dermatol
; 20(2): 74-8, 1993 Feb.
Article
en En
| MEDLINE
| ID: mdl-8478489
ABSTRACT
Ultraviolet-B and PUVA share several biological events with phorbol ester tumor promoters. The effects of ultraviolet-B irradiation and topical PUVA treatment on ornithine decarboxylase activity, DNA synthesis, and protein kinase C activity, which are known to be induced or activated by phorbol ester tumor promoter, were investigated in hairless mouse skin. Ornithine decarboxylase activity was remarkably enhanced by ultraviolet-B and PUVA. Although PUVA did not affect DNA synthesis significantly, ultraviolet-B stimulated epidermal DNA synthesis approximately 5-fold over control values at 48 h. However, unexpectedly, neither cytosolic nor membrane-bound protein kinase C activity showed any change during the 2 h after either treatment. These results suggest that the protein kinase C system is not involved in the initial signal transduction system of ultraviolet-B or PUVA, unlike the case with phorbol ester tumor promoter.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Ornitina Descarboxilasa
/
Terapia PUVA
/
Piel
/
Rayos Ultravioleta
/
Proteína Quinasa C
/
ADN
Idioma:
En
Revista:
J Dermatol
Año:
1993
Tipo del documento:
Article
País de afiliación:
Japón