Antagonism of the presumed presynaptic action of L-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR antagonist MPPG.
Neuropharmacology
; 35(2): 239-41, 1996 Feb.
Article
en En
| MEDLINE
| ID: mdl-8734494
ABSTRACT
The metabotropic glutamate receptor (mGluR) agonists CCG-I and L-AP4, acting at Group II and Group III mGluRs respectively, can reduce GABAergic synaptic inhibition on single neurones in the rat thalamus in vivo via a presumed presynaptic mechanism. The actions of L-AP4 were antagonized by (+/-)-alpha-methyl-4-phosphonophenylglycine (MPPG), whereas CCG-I was significantly less affected. Thus MPPG may be a useful tool for detecting physiological roles for Group III mGluRs.
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Bases de datos:
MEDLINE
Asunto principal:
Tálamo
/
Receptores de Glutamato Metabotrópico
/
Agonistas de Aminoácidos Excitadores
/
Alanina
/
Potenciales Evocados Somatosensoriales
/
Aminobutiratos
Idioma:
En
Revista:
Neuropharmacology
Año:
1996
Tipo del documento:
Article
País de afiliación:
Reino Unido