In vitro effects of hyperthermia combined with cisplatin or peplomycin on the human maxillary carcinoma cell line IMC-2.
Int J Hyperthermia
; 13(1): 59-67, 1997.
Article
en En
| MEDLINE
| ID: mdl-9024927
ABSTRACT
We examined the interactive effects of hyperthermia combined with cisplatin (CDDP) (0.5 micrograms/ml) or peplomycin (PEP) (1.0 microgram/ml) on surviving fractions of human maxillary carcinoma IMC-2 cells. Either CDDP or PEP enhanced the 44 degree C thermosensitivity of thermotolerant cells after heating at 42 degrees C for 2 hours. The development of thermotolerance at 42 degrees C with either of the two drugs for 2 hours was not inhibited by CDDP, but it was partially inhibited by PEP. Moreover, for PEP throughout the entire period of 42-44 degrees C step-up heating, the 44 degree C thermosensitivity of thermotolerant cells after heating at 42 degrees C with PEP for 2 hours was enhanced similarly to that at 44 degrees C with PEP. Heating at 42 degrees C combined with either of the two drugs showed a marked interactive effect.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Maxilares
/
Cisplatino
/
Peplomicina
/
Hipertermia Inducida
/
Antineoplásicos
Idioma:
En
Revista:
Int J Hyperthermia
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón