Fluorometric determination of methyldopa in biological fluids.
J Pharm Sci
; 66(11): 1632-4, 1977 Nov.
Article
en En
| MEDLINE
| ID: mdl-915747
ABSTRACT
A fluorometric method for the analysis of methyldopa, based on the formation of a fluorophore after oxidation and rearrangement, is described. The drug is isolated from biological fluids by adsorption on alumina and elution with an organic solvent. Fluoresence is linear from 0.1 to 1.5 microgram of methyldopa/ml. The assay has a lower limit of sensitivity of 100 ng/ml and is suitable for pharmacokinetic studies following therapeutic doses in animals and humans.
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Bases de datos:
MEDLINE
Asunto principal:
Metildopa
Idioma:
En
Revista:
J Pharm Sci
Año:
1977
Tipo del documento:
Article