Two cases of MND/ALS developing the syndrome of inappropriate secretion of antidiuretic hormone.
Acta Neurol Scand
; 96(4): 262-5, 1997 Oct.
Article
en En
| MEDLINE
| ID: mdl-9325481
ABSTRACT
We report 2 autopsy-proven cases of motor neuron disease/amyotrophic lateral sclerosis (MND/ALS), who developed the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) prior to the respiratory failure. With respect to the underlying mechanisms of SIADH in the cases, we considered two factors; 1) dysfunction of the feedback system in ADH secretion via intrathoracic volume receptors caused by changes in intrathoracic circulation, and 2) primarily functional abnormalities in the limbic system which could influence hypothalamic osmoreceptors. It appears that SIADH can be followed by an exacerbation of respiratory dysfunction in MND/ALS.
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Bases de datos:
MEDLINE
Asunto principal:
Enfermedad de la Neurona Motora
/
Esclerosis Amiotrófica Lateral
/
Síndrome de Secreción Inadecuada de ADH
Idioma:
En
Revista:
Acta Neurol Scand
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón