Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Planta Med
; 63(6): 529-32, 1997 Dec.
Article
en En
| MEDLINE
| ID: mdl-9434605
ABSTRACT
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
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Bases de datos:
MEDLINE
Asunto principal:
Plantas Tóxicas
/
Globulina de Unión a Hormona Sexual
/
Lignanos
/
Raíces de Plantas
Idioma:
En
Revista:
Planta Med
Año:
1997
Tipo del documento:
Article
País de afiliación:
Alemania