Long-term food restriction, deprenyl, and nimodipine treatment on life expectancy and blood pressure of stroke-prone rats.
Neurobiol Aging
; 19(3): 273-6, 1998.
Article
en En
| MEDLINE
| ID: mdl-9662003
ABSTRACT
We determined whether food restriction or the drugs nimodipine (Ca2+ antagonist) and deprenyl (a MAO-B inhibitor) prevent the development of stroke in the spontaneously hypertensive stroke-prone rat (SHR-SP). Forty male SHR-SP rats, in the age of 34 weeks, were exposed to various treatments. During a period of 27 weeks, survival and blood pressure were followed. In the control and deprenyl group, the blood pressure values remained unchanged; 50% had died after 27 weeks. All rats that were treated with nimodipine survived. After food restriction, 7/8 rats survived and showed a lower blood pressure. This study in SHR-PR rats shows the superiority of nimodipine on survival, and the potential of food restriction as a stroke-preventing measure.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
Asunto principal:
Presión Sanguínea
/
Selegilina
/
Bloqueadores de los Canales de Calcio
/
Nimodipina
/
Trastornos Cerebrovasculares
/
Privación de Alimentos
/
Longevidad
/
Inhibidores de la Monoaminooxidasa
Idioma:
En
Revista:
Neurobiol Aging
Año:
1998
Tipo del documento:
Article
País de afiliación:
Países Bajos