Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity.
J Med Chem
; 41(23): 4542-9, 1998 Nov 05.
Article
en En
| MEDLINE
| ID: mdl-9804693
ABSTRACT
A series of psoralens and structurally related 5,7-disubstituted coumarins was synthesized and investigated for their K+ channel blocking activity as well as for their phototoxicity to Artemia salina and their ability to generate singlet oxygen and to photomodify DNA. After screening the compounds on Ranvier nodes of the toad Xenopus laevis, the affinities of the most promising compounds, which proved to be psoralens bearing alkoxy substituents in the 5-position or alkoxymethyl substituents in the neighboring 4- or 4'-position, to a number of homomeric K+ channels were characterized. All compounds exhibited the highest affinity to Kv1.2. 5,8-Diethoxypsoralen (10d) was found to be an equally potent inhibitor of Kv1.2 and Kv1.3, while lacking the phototoxicity normally inherent in psoralens. The reported compounds represent a novel series of nonpeptide blockers of Shaker-type K+ channels that could be further developed into selective inhibitors of Kv1.2 or Kv1. 3.
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Bases de datos:
MEDLINE
Asunto principal:
Furocumarinas
/
Rayos Ultravioleta
/
Canales de Potasio
/
Bloqueadores de los Canales de Potasio
Idioma:
En
Revista:
J Med Chem
Año:
1998
Tipo del documento:
Article
País de afiliación:
Alemania