Isolation and structure elucidation of new PKCalpha inhibitors from Pinus flexilis.
J Nat Prod
; 61(11): 1407-9, 1998 Nov.
Article
en En
| MEDLINE
| ID: mdl-9834165
ABSTRACT
Bioassay-guided fractionation of the CH2Cl2-MeOH extract of Pinus flexilis using an assay for protein kinase C (PKC) inhibitory activity led to the isolation of the two new bioactive diarylheptanoids (3R)-1,7-bis(3, 4-dihydroxyphenyl)-3-(beta-D-glucopyranosyl)heptan-3-ol (1) and its aglycon (3R)-1,7-bis(3,4-dihydroxyphenyl)heptan-3-ol (2), together with the three known bioactive compounds, hirsutenone (3), oregonin (4), and hirsutanonol (5). The IC50 values of compounds 1-5 in the PKC assay were 1.4, 1.6, 1.4, 8.6, and 4.6 microg/mL, respectively.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Plantas Medicinales
/
Proteína Quinasa C
/
Heptanol
/
Diarilheptanoides
/
Inhibidores Enzimáticos
/
Glucosa
/
Isoenzimas
Idioma:
En
Revista:
J Nat Prod
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos