Your browser doesn't support javascript.
loading
Optimization of daily folate, vitamin B12 and vitamin B6 supplements in paediatric patients with sickle cell disease
van der Dijs, F. P. L; Fokkema, M. R; Brouwer, D. A. J; Niessink, B; van der Wal, T. I. C; Schnog, J. J; Dutis, A. J; Muskiet, F. D; Muskiet, Frits A. J.
Afiliación
  • van der Dijs, F. P. L; Public Health Laboratory, Curacao, NA
  • Fokkema, M. R; Groningen University Hospital, Groningen, The Netherlands
  • Brouwer, D. A. J; Groningen University Hospital, Groningen, The Netherlands
  • Niessink, B; Groningen University Hospital, Groningen, The Netherlands
  • van der Wal, T. I. C; Groningen University Hospital, Groningen, The Netherlands
  • Schnog, J. J; Groningen University Hospital, Groningen, The Netherlands
  • Dutis, A. J; Groningen University Hospital, Groningen, The Netherlands
  • Muskiet, F. D; St. Elizabeth Hospital, Curacao, NA
  • Muskiet, Frits A. J; St. Elizabeth Hospital, Curacao, NA
West Indian med. j ; West Indian med. j;49(Supp 2): 39, Apr. 2000.
Article en En | MedCarib | ID: med-948
Biblioteca responsable: JM3.1
Ubicación: JM3.1; R18.W4
ABSTRACT
We determined optimal folate, vitamin B12 and vitamin B6 dosages in 21 sickle cell disease (SCD) patients (11 HbSS, 10 HbSC; mean 7 years, range 7-16), using plasma homocysteine (Hcy) as functional marker. They received daily 400 g (0-3 weeks), 700 g (3-6) and 1000 g (6-70) folate; 1 (0-21), 3 (21-45 and 5 RDA (45-70) vitamin B12; and 1 RDA vitamin B6 (0-70). Blood was taken at baseline (P0) and after 3 (PI), 6 (P2), 9 (P3), 21 (P4), 33 (P5), 45 (P6), 57 (P7) and 70 (P8) weeks for measurement of erythrocyte (RBC), serum folate, plasma vitamin B12, whole blood vitamin B6 and plasma Hcy. Vitamin B6 increased from P0 to P1 and P1 to P2; vitamin B12 from P4 to P8; serum folate from P0 to P1 and P1 to P2; RBC folate from P0 to P1, P1 to P2 and P2 to P3. Hcy decreased from P1 to P2 and P4 to P6. Most pronounced Hcy decreases occurred from P0 to P1 (43 percent of patients), P1 to P2 (14 percent) and P4 to P5 (24 percent). Haematological indices did not change. Patients with HbSS had higher RBC folate at P1, P2 and P8. The entire group exhibited inverse relations between RBC folate and haemoglobin on P1, P2, P3, P6, P7 and P8. We conclude that RBC folate is less valuable for folate status assessment in SCD patients. The optimal daily supplement is 700 g folate (3.5-7 RDA vitamin B12 (4.2-6.0 g) and 1 RDA vitamin B6 (1.4-2.0 mg). This combination causes Hcy levels that do not decrease further upon higher dosages and may reduce by simple and relatively inexpensive means their inherently high risk of endothelial damage.(Au)
Asunto(s)
Buscar en Google
Bases de datos: MedCarib Asunto principal: Deficiencia de Vitamina B 6 / Deficiencia de Vitamina B 12 / Ácidos Pteroilpoliglutámicos / Anemia de Células Falciformes Idioma: En Revista: West Indian med. j Año: 2000 Tipo del documento: Article
Buscar en Google
Bases de datos: MedCarib Asunto principal: Deficiencia de Vitamina B 6 / Deficiencia de Vitamina B 12 / Ácidos Pteroilpoliglutámicos / Anemia de Células Falciformes Idioma: En Revista: West Indian med. j Año: 2000 Tipo del documento: Article