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Hypopituitarism Presenting as Adrenal Insufficiency and Hypothyroidism in a Patient with Wilson's Disease: a Case Report
Article en En | WPRIM | ID: wpr-143607
Biblioteca responsable: WPRO
ABSTRACT
Wilson's disease typically presents symptoms associated with liver damage or neuropsychiatric disturbances, while endocrinologic abnormalities are rare. We report an unprecedented case of hypopituitarism in a patient with Wilson's disease. A 40-year-old woman presented with depression, general weakness and anorexia. Laboratory tests and imaging studies were compatible with liver cirrhosis due to Wilson's disease. Basal hormone levels and pituitary function tests indicated secondary hypothyroidism and adrenal insufficiency due to hypopituitarism. Brain MRI showed T2 hyperintense signals in both basal ganglia and midbrain but the pituitary imaging was normal. She is currently receiving chelation therapy along with thyroid hormone and steroid replacement. There may be a relationship between Wilson's disease and hypopituitarism. Copper deposition or secondary neuronal damage in the pituitary may be a possible explanation for this theory.
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Texto completo: 1 Bases de datos: WPRIM Asunto principal: Esteroides / Encéfalo / Imagen por Resonancia Magnética / Hormona Liberadora de Tirotropina / Insuficiencia Suprarrenal / Depresión / Degeneración Hepatolenticular / Hipopituitarismo / Hipotiroidismo / Cirrosis Hepática Idioma: En Revista: Journal of Korean Medical Science Año: 2016 Tipo del documento: Article
Texto completo: 1 Bases de datos: WPRIM Asunto principal: Esteroides / Encéfalo / Imagen por Resonancia Magnética / Hormona Liberadora de Tirotropina / Insuficiencia Suprarrenal / Depresión / Degeneración Hepatolenticular / Hipopituitarismo / Hipotiroidismo / Cirrosis Hepática Idioma: En Revista: Journal of Korean Medical Science Año: 2016 Tipo del documento: Article