Effects of Add-On Therapy with NDC-052, an Extract from Magnoliae Flos, in Adult Asthmatic Patients Receiving Inhaled Corticosteroids
The Korean Journal of Internal Medicine
; : 84-90, 2012.
Article
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| WPRIM
| ID: wpr-181913
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: There is a need for new anti-asthmatic medications with fewer side effects. NDC-052, an extract of the medicinal herb Magnoliae flos, which has a long history of clinical use, was recently found to have anti-inflammatory effects. Herein, we evaluated the effects of NDC-052 as an add-on therapy in patients with mild to moderate asthma using inhaled corticosteroids (ICS). METHODS: In a non-comparative, multi-center trial, 148 patients taking ICS received NDC-052 for eight weeks. We evaluated their forced expiratory volume in one second (FEV1), morning and evening peak expiratory flow rate (AM and PM PEFR), AM/PM asthma symptom scores, visual analogue symptom (VAS) scores, night-time wakening, frequency of short-acting beta2-agonist usage, and adverse events. RESULTS: After eight weeks, both AM and PM PEFRs were significantly improved. Asthma symptom scores, VAS scores, the frequency of nights without awakening, and the frequency of beta2-agonist use were also reduced. Most of the adverse drug reactions were mild and resolved spontaneously. CONCLUSIONS: The addition of NDC-052 to ICS had a beneficial effect on asthma control in patients with mild to moderate asthma, with good tolerability and fewer side effects. Further studies are necessary to evaluate the effects of NDC-052 in patients with severe and/or refractory asthma.
Palabras clave
Texto completo:
1
Bases de datos:
WPRIM
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
Asunto principal:
Asma
/
Factores de Tiempo
/
Índice de Severidad de la Enfermedad
/
Administración por Inhalación
/
Medicamentos Herbarios Chinos
/
Ápice del Flujo Espiratorio
/
Volumen Espiratorio Forzado
/
Estudios Prospectivos
/
Resultado del Tratamiento
/
Corticoesteroides
Tipo de estudio:
Clinical_trials
/
Observational_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
The Korean Journal of Internal Medicine
Año:
2012
Tipo del documento:
Article