Studies on protective effects of Niuhuang Shangqing pills on cerebral ischemia / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 943-948, 2007.
Article
en Zh
| WPRIM
| ID: wpr-235284
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the protective effect of Niuhuang Shangqing pills (NSP) on the experimental cerebral ischemia and the influence of blood rheology in animals.</p><p><b>METHOD</b>Using the middle cerebral artery occlusion (MCAO), bilateral common carotid artery ligation and lipopolysaccharide (LPS) in combination with carrogeenin (Ca)-induced stagnation of blood model rats, we investigated the influence of NSP on the physical sign indexes, brain infarct size and the water content, the content of lactate(LD), glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA) and the blood rheology.</p><p><b>RESULT</b>The 3.00, 1.50 g x kg(-1) dosage groups of NSP decreased the neurosigns indexes, significantly reduced the brain infarct areas in MCAO rats, decreased the brain water content, increased the activities of GPx and CAT, decreased the content of LD and MDA in bilateral common carotid artery ligation rats. They improved the blood rheology in lipopolysaccharide (LPS) in combination with carrogeenin (Ca)-induced stagnation of blood model rats.</p><p><b>CONCLUSION</b>NSP has the function of protective effect on experimental experimental cerebral ischemia.</p>
Texto completo:
1
Bases de datos:
WPRIM
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Asunto principal:
Patología
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Farmacología
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Plantas Medicinales
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Sangre
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Viscosidad Sanguínea
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Encéfalo
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Medicamentos Herbarios Chinos
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Catalasa
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Distribución Aleatoria
/
Isquemia Encefálica
Tipo de estudio:
Diagnostic_studies
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2007
Tipo del documento:
Article