Optimization of extraction conditions for semi-bionic extraction of Guizhi Fuling pill decoction by uniform design / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To optimize the extraction conditions for semi-bionic extraction of Guizhi Fuling pill decoction.</p><p><b>METHOD</b>The best extraction condition of the semi-bionic extraction for Guizhi Fuling pill decoction was optimized by uniform design was optimized with paeoniflorin, cinnamic acid, laetrile, pachymic acid, total polysaccharose and dry extract as the indexes.</p><p><b>RESULT</b>The optimized extraction condition is that extracting for 3 times with solvent pH values of 4.98, 7.35 and 8.00, respectively, and the total extracting time was 4.99 h.</p><p><b>CONCLUSION</b>In consideration of manufacturing fact, the pH value of thrice extractions is set at 5.0, 7.5, 8.0 respectively, and the extracting time is 2.0, 1.5, 1.5 h in turn.</p>