Protective effect of ligusticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 466-468, 2005.
Article
en Zh
| WPRIM
| ID: wpr-279137
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effect of ligusticum chuanxiong phthalides on cerebral ischemia in rats and its related mechanism of action.</p><p><b>METHOD</b>Middle cerebral artery occlusion (MCAO) model, thrombosis formation, platelet aggregation and hemorrheological parameters were measured to evaluate the protective effect of ligusticum chuanxiong phthalides.</p><p><b>RESULT</b>Ligusticum chuanxiong phthalides could markedly decrease the infarct size and behavior deficits score, inhibit the thrombus formation and platelet aggregation, ameliorate hemorrheological parameters with a dose-dependent manner in rats.</p><p><b>CONCLUSION</b>Ligusticum chuanxiong phthalides has protective effects on focal cerebral ischemia in rats, and its mechanism may be relevant to its inhibition of platelet-dependent thrombosis and amelioration of hemorrheological parameters.</p>
Texto completo:
1
Bases de datos:
WPRIM
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Patología
/
Farmacología
/
Plantas Medicinales
/
Benzofuranos
/
Sangre
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Viscosidad Sanguínea
/
Isquemia Encefálica
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Química
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Agregación Plaquetaria
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Ratas Wistar
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2005
Tipo del documento:
Article