Effects of di'ao xinxuekang soft capsule on lipid peroxidation and the endothelial function in patients with coronary heart disease / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 782-784, 2012.
Article
en Zh
| WPRIM
| ID: wpr-288520
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of Di' ao Xinxuekang Soft Capsule (DK) on the plasma levels of superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), and endothelin (ET) in patients with coronary heart disease (CHD), and to study its underlying mechanisms.</p><p><b>METHODS</b>Totally 100 patients with CHD confirmed by coronary angiography were randomly assigned to two groups, the control group (60 cases) and the DK treatment group (40 cases). Patients in the control group received conventional therapy, while those in the DK treatment group received DK additionally. The therapeutic course for all was 3 months. The plasma levels of SOD, MDA, ET, and NO were determined pre-treatment, 4, 8, and 12 weeks after treatment.</p><p><b>RESULTS</b>Compared with before treatment, the serum levels of SOD and NO increased and the levels of MDA and ET decreased at each time point. Besides, better effects were obtained in the DK treatment group (P < 0.05).</p><p><b>CONCLUSION</b>DK possibly played a role in inhibiting lipid peroxidation and improving the endothelial dysfunction.</p>
Texto completo:
1
Bases de datos:
WPRIM
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Superóxido Dismutasa
/
Sangre
/
Medicamentos Herbarios Chinos
/
Endotelio Vascular
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Peroxidación de Lípido
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Endotelinas
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Enfermedad Coronaria
/
Usos Terapéuticos
/
Quimioterapia
/
Malondialdehído
Idioma:
Zh
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2012
Tipo del documento:
Article