Study on in vitro metabolic rate and metabolites or 9-dehydro-17-dehydro-andrographolide / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 971-977, 2015.
Article
en Zh
| WPRIM
| ID: wpr-330201
Biblioteca responsable:
WPRO
ABSTRACT
To investigate the metabolic rate and metabolites of 9-dehydro-17-dehydro-andrographolide, which is the main active ingredient in Xiyanping injection, by using the in vitro rat liver microsome incubation system. 9-dehydro-17-dehydro-andrographolide was incubated together with liver microsome mixed with NADPH. Its metabolic rate was studied by determining its residual concentrations with the UHPLC-MS/MS method; Its metabolites were identified by the UPLC-TOF-MS(E) method. The results showed that 9-dehydro-17-dehydro-andrographolide was metabolized faster than rat liver microsomes mixed with coenzymes, with t½ and CL of (19.7 ± 0.5) min and (35.1 ± 0.8) mL x min(-1) x g(-1) (protein), respectively. Based on the high resolution mass spectrum data and information from literatures, altogether nine metabolites of 9-dehydro-17-dehydro-andrographolide were identified in the incubation system, particularly hydroxylated and dehydrogenized products. The results of identification would provide a basis for screening out more active andrographolide derivatives.
Texto completo:
1
Bases de datos:
WPRIM
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Asunto principal:
Microsomas Hepáticos
/
Medicamentos Herbarios Chinos
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Estructura Molecular
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Química
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Cromatografía Líquida de Alta Presión
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Diterpenos
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Espectrometría de Masas en Tándem
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Metabolismo
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2015
Tipo del documento:
Article