Effect of aralosides to contraction function and calcium transient of ischemia/reperfusion myocardial cells / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2403-2407, 2015.
Article
en Zh
| WPRIM
| ID: wpr-337921
Biblioteca responsable:
WPRO
ABSTRACT
To discuss the protective effect of aralosides (AS) on I/R-induced rat myocardial injury. The adult rat ventricular myocyte ischemia model was established through perfusion with sodium lactate perfusate and reperfusion with Ca(2+) -containing Tyrode's solution simulation. The cell contraction and ion concentration synchronization determination system was applied to detect the effect of AS on single I/R cell contraction and Ca2+ transients. According to the findings, AS could increase resting sarcomere length, contraction amplitude, ± dL/dt(max), calcium transient amplitude and speed of post-reperfusion myocardial cells (P < 0.05, P < 0.01), and decrease in time for achieving 90.0% of maximum relaxation, time for achieving peak value, resting calcium ratio, contraction period [Ca2+] i, time for achieving 50.0% of maximum relaxation and attenuation rate of intracellular calcium transient (P < 0.05, P < 0.01). Therefore, it is suggested that AS improved the post-reperfusion cell contraction and injury of calcium homeostasis.
Texto completo:
1
Bases de datos:
WPRIM
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Asunto principal:
Fisiología
/
Saponinas
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Cirugía General
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Transporte Biológico
/
Medicamentos Herbarios Chinos
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Reperfusión Miocárdica
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Química
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Calcio
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Ratas Sprague-Dawley
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Isquemia Miocárdica
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2015
Tipo del documento:
Article