Study on absorption ingredients of yuanhuzhitong pill by everted intestinal sac method / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2005-2011, 2012.
Article
en Zh
| WPRIM
| ID: wpr-338715
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To establish an everted intestinal sac method for determining absorption ingredients of yuanhuzhitong pill and study absorption characteristics of major chemical constituents of yuanhuzhitong pill.</p><p><b>METHOD</b>The everted intestinal sac model was adopted. Intestinal sac fluid samples at different time points after administration of three concentrations of Yuanhuzhitong pill were collected and determined by HPLC. The accumulative absorbed doses of active constituents were calculated, while the proportion between samples of yuanhuzhitong pill and absorption ingredients was compared.</p><p><b>RESULT</b>Eight ingredients of Yuanhuzhitong pill can be detected in intestinal sac, they are protopine, palmatine, coptisine, imperatorin, berberine, byakangelicin, alpha-allocryptopine and tetrahydropalmatine. The absorption rate constants (Ka) of eight constituents increased in jejunum and ileum with the increase in concentration of Yuanhuzhitong pill extracts (P < 0. 05), indicating a passive absorption.</p><p><b>CONCLUSION</b>As ingredients are selectively absorbed in intestinal sac, the everted intestinal sac method is selected to assess the intestinal absorption characteristics of ingredients of Yuanhuzhitong prescription.</p>
Texto completo:
1
Bases de datos:
WPRIM
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Asunto principal:
Medicamentos Herbarios Chinos
/
Farmacocinética
/
Química
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Cromatografía Líquida de Alta Presión
/
Ratas Sprague-Dawley
/
Angelica
/
Corydalis
/
Absorción Intestinal
/
Intestinos
/
Medicina Tradicional China
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2012
Tipo del documento:
Article